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“During the period of Omicron predominance, the pattern was similar, although all VE estimates were significantly lower. VE against COVID-19–associated ED and UC encounters 14–179 days after receipt of dose 2 was 52%, and at ≥180 days after dose 2 was 38%. VE after receipt of 3 vaccine doses among all adults was 82%.”
This report describes COVID-19 vaccine effectiveness time frames among people who received their first and second doses of the vaccine series, and effectiveness of third vaccine doses during both Delta- and Omicron-predominant periods.
www.cdc.gov
“CDC recommends that all persons aged ≥12 years receive a third dose (booster) of an mRNA vaccine ≥5 months after receipt of the second mRNA vaccine dose and that immunocompromised individuals receive a third primary dose.† A third dose of BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine increases neutralizing antibody levels (
4), and three recent studies from Israel have shown improved effectiveness of a third dose in preventing COVID-19 associated with infections with the SARS-CoV-2 B.1.617.2 (Delta) variant (
5–
7). Yet, data are limited on the real-world effectiveness of third doses of COVID-19 mRNA vaccine in the United States, especially since the SARS-CoV-2 B.1.1.529 (Omicron) variant became predominant in mid-December 2021. “